A Bayesian Hierarchical Model for Detecting Haplotype-Haplotype and Haplotype-Environment Interactions in Genetic Association Studies
نویسندگان
چکیده
منابع مشابه
A Bayesian hierarchical model for detecting haplotype-haplotype and haplotype-environment interactions in genetic association studies.
OBJECTIVE Genetic association studies based on haplotypes are powerful in the discovery and characterization of the genetic basis of complex human diseases. However, statistical methods for detecting haplotype-haplotype and haplotype-environment interactions have not yet been fully developed owing to the difficulties encountered: large numbers of potential haplotypes and unknown haplotype pairs...
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Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature. In this article, we describe a statistical model for testing haplotype-haplotype interactions for human diseases with a case-control genetic ass...
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2011
ISSN: 1423-0062,0001-5652
DOI: 10.1159/000324841